Increased Frequency of Dermatological Diseases in Parkinson's Patients
Abstract
Objective: To determine the frequency of seborrheic dermatitis, bullous pemphigoid, rosacea, and melanoma
among the patients diagnosed with Parkinson Disease.
Study Design: Cross sectional study.
Place and Duration of Study: The study was carried out at Dermatology Department of Bakhtawar Amin Trust
th th Teaching Hospital Multan from 13 May to 13 October 2020.
Materials and Methods: A total of 80 patients of Parkinson disease were evaluated for skin disorders. Disease
severity was confirmed through Hoehn Yahr staging criteria (H-Y stage). Skin characteristics and disease
diagnosis was made through finding sebum production levels, hot/cold flush test, immunofluorescence and
biopsy evaluation for seborrheic dermatitis, rosacea, bullous pemphigoid, and melanoma, respectively. The
test results were compared with control subject. Chi square test and student t-test were used to find the
significance of results. P < 0.05 will be statistically significant.
Results: Out of 80, 44 patients were positive for skin disorders. The frequency of seborrheic dermatitis was
31.2% and was quite high as compared to control group that was 25% whereas rosacea, bullous pemphigoid
and melanoma was found in 15%, 6.2% and 2.5% patients and in control group they were 11.2%, 2.5% and 1.0%
respectively. To detect the significant difference between quantitative variables of test and control group, chi
square was used and student t-test was used to compare the qualitative variables. P < 0.05 will be statistically
significant.
Conclusion: Skin disorders are highly prevalent among Parkinson's patients than control population.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
References
Simon DK, Tanner CM, Brundin P. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.
Clinics in Geriatric Medicine. 2020; 36: 1-12.
Sung VW, Nicholas AP. Nonmotor Symptoms in Parkinson's Disease: Expanding the View of Parkinson's Disease Beyond a Pure Motor, Pure Dopaminergic Problem. Neurologic Clinics. 2013; 31: S1-S16.
Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. Journal of Neural Transmission. 2017; 124: 901-5.
Moustafa AA, Chakravarthy S, Phillips JR, Gupta A, Keri S, Polner B, et al. Motor symptoms in Parkinson's disease: A unified framework. Neuroscience & Biobehavioral Reviews. 2016; 68: 727-40.
Gros P, Videnovic A. Overview of sleep and circadian rhythm disorders in Parkinson disease. Clinics in geriatric medicine. 2020; 36: 119-30.
Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and
management. The Lancet Neurology. 2006; 5: 235-45.
Gregory R, Miller S. Parkinson's disease and the skin. Practical Neurology. 2015; 15: 246-9.
Ravn AH, Thyssen JP, Egeberg A. Skin disorders in Parkinson's disease: potential biomarkers and risk factors.
Clin Cosmet Investig Dermatol. 2017; 10: 87-92.
Qassem M, Kyriacou P. Review of modern techniques for the assessment of skin hydration. Cosmetics. 2019; 6: 19.
Qin J, Qiao L, Hu J, Xu J, Du L, Wang Q, et al. New method for large-scale facial skin sebum quantification and skin type classification. Journal of Cosmetic Dermatology. 2021; 20: 677-83.
Algiert-Zielińska B, Mucha P, Rotsztejn H. Comparative evaluation of skin moisture after topical application of 10% and 30% lactobionic acid. Journal of cosmetic dermatology. 2018; 17: 1096-100.
Shahid W, Satyjeet F, Kumari R, Raj K, Kumar V, Afroz MN, et al. Dermatological Manifestations of Parkinson's Disease: Clues for Diagnosis. Cureus. 2020; 12: e10836-e.13. Arsenijevic VSA, Milobratovic D, Barac AM, Vekic B,
Marinkovic J, Kostic VS. A laboratory-based study on patients with Parkinson's disease and seborrheic
dermatitis: the presence and density of Malassezia yeasts, their different species and enzymes production. BMC
dermatology. 2014; 14: 1-9.
Adalsteinsson JA, Kaushik S, Muzumdar S, Guttman-Yassky E, Ungar J. An update on the microbiology, immunology and genetics of seborrheic dermatitis. Experimental dermatology. 2020; 29: 481-9.
Kavita R. Gandhi and Abdolreza Saadabadi. Levodopa (LDopa). Statpearls. 2021.
Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Exploring the association between rosacea and Parkinson disease: a Danish nationwide cohort study. JAMA neurology. 2016; 73:529-34.
Cordel N, Chosidow O, Hellot MF, Delaporte E, Lok C, Vaillant L, et al. Neurological disorders in patients with
bullous pemphigoid. Dermatology. 2007; 215: 187-91.
Brick KE, Weaver CH, Savica R, Lohse CM, Pittelkow MR, Boeve BF, et al. A population-based study of the association between bullous pemphigoid and neurologic disorders. Journal of the American Academy of Dermatology. 2014; 71: 1191-7.
Liu R, Gao X, Lu Y, Chen H. Meta-analysis of the relationship between Parkinson disease and melanoma. Neurology. 2011; 76: 2002-9.
Tanaka J, Henderson C, Nicholas MW. Skin Disease and Neurological Conditions of the Elderly. Current Geriatrics Reports. 2018; 7: 238-42.
Pan T, Zhu J, Hwu WJ, Jankovic J. The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS One. 2012; 7: e45183.
